SCHEMBL3814798

SCHEMBL3814798

CS(=O)(=O)Nc1cccc(CC(c2ccc(Cl)cc2)(c2cccnc2)c2cccnc2)n1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 8/20 0.43
KCNA5 P22460 2/20 0.39
KCNE1 P15382 1/20 0.39
KCNQ1 P51787 1/20 0.39
KCND3 Q9UK17 1/20 0.39
PTGER2 P43116 1/20 0.38
CTPS1 P17812 1/20 0.38
PTGS1 P23219 2/20 0.37
PTGS2 P35354 2/20 0.37
CYP3A4 P08684 1/20 0.37
CYP3A5 P20815 1/20 0.37
NR3C2 P08235 1/20 0.37
TGFBR1 P36897 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
NAMPT P43490 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1378202 0.89 PTGER2 (0.44) KCNA5KCNE1KCNQ1KCND3PTGER2
SCHEMBL1378598 0.89 KCNA5 (0.51) KCNA5KCNE1KCNQ1KCND3PTGER2
SCHEMBL1378483 0.89 KCNA5 (0.38) CYP19A1KCNA5KCNE1KCNQ1KCND3
SCHEMBL3814688 0.84 KCNA5 (0.37) CYP19A1KCNA5KCNE1KCNQ1KCND3
SCHEMBL1381975 0.83 KCNA5 (0.45) KCNA5KCNE1KCNQ1KCND3PTGER2
SCHEMBL3819011 0.82 HSD11B1 (0.39) KCNA5KCNE1KCNQ1KCND3PTGER2
SCHEMBL3811774 0.81 KCNA5 (0.45) KCNA5KCNE1KCNQ1KCND3PTGER2
SCHEMBL1378033 0.80 KCNA5 (0.43) KCNA5KCNE1KCNQ1KCND3PTGER2
SCHEMBL1381518 0.80 KCNA5 (0.37) KCNA5KCNE1KCNQ1KCND3PTGER2
SCHEMBL1379410 0.79 KCNA5 (0.37) KCNA5KCNE1KCNQ1KCND3PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1776355-A4 POTASSIUM CHANNEL INHIBITORS MERCK & CO INC (US) 2009-08-12 EP disclosed
EP-1776355-A2 POTASSIUM CHANNEL INHIBITORS Merck & Co., Inc. (US) 2007-04-25 EP disclosed
WO-2006014877-A2 POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2006-02-09 WO disclosed