Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3816607 | 0.88 | KMT2A (0.42) | MEN1KMT2ADRD1GRM5TRPC3 | |
| SCHEMBL3816872 | 0.88 | HTT (0.37) | MEN1KMT2AGRM5HTTGAA | |
| SCHEMBL3812114 | 0.87 | DRD1 (0.49) | MEN1KMT2ADRD1GRM5TRPC3 | |
| SCHEMBL3824223 | 0.87 | DRD1 (0.49) | MEN1KMT2ADRD1GRM5TRPC3 | |
| SCHEMBL8012792 | 0.87 | DRD1 (0.49) | MEN1KMT2ADRD1GRM5TRPC3 | |
| SCHEMBL3811755 | 0.86 | KMT2A (0.43) | MEN1KMT2ADRD1QRFPRHTT | |
| SCHEMBL3810668 | 0.85 | KMT2A (0.41) | MEN1KMT2ADRD1GRM5HTT | |
| SCHEMBL3820674 | 0.84 | P2RX7 (0.37) | MEN1KMT2ADRD1QRFPRGRM5 | |
| SCHEMBL3812712 | 0.84 | KMT2A (0.41) | MEN1KMT2ADRD1QRFPRHTT | |
| SCHEMBL3816636 | 0.84 | KMT2A (0.41) | MEN1KMT2ADRD1GRM5PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |