Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16504458 | 0.90 | CFD (0.41) | CFDCXCL8NOTUMOPRM1CTSA | |
| SCHEMBL16504457 | 0.90 | CFD (0.41) | CFDCXCL8NOTUMOPRM1CTSA | |
| SCHEMBL19244855 | 0.86 | MEN1 (0.41) | CXCL8OPRM1MEN1KMT2A | |
| SCHEMBL382379 | 0.86 | NISCH (0.43) | CXCL8OPRM1ADRB2ADRB1 | |
| SCHEMBL16504550 | 0.86 | CFD (0.40) | CFDCXCL8NOTUMOPRM1MRGPRX4 | |
| SCHEMBL16504549 | 0.86 | CFD (0.40) | CFDCXCL8NOTUMOPRM1MRGPRX4 | |
| SCHEMBL15772238 | 0.78 | CFD (0.36) | CFDCXCL8SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15772237 | 0.78 | CFD (0.36) | CFDCXCL8SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL381228 | 0.76 | MEN1 (0.39) | CXCL8OPRM1MEN1KMT2A | |
| SCHEMBL382428 | 0.76 | ACP3 (0.43) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408751-B1 | Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | BAYER IP GMBH (DE) | 2017-08-23 | — | — | EP | disclosed |
| EP-2408751-A1 | Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | Bayer Pharma Aktiengesellschaft (DE) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010105770-A1 | SUBSTITUTED 2-ACETAMIDO-5-ARYL-1,2,4-TRIAZOLONES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-09-23 | — | — | WO | disclosed |