Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 11/20 | 0.38 |
| ▸ | GRM5 | P41594 | 6/20 | 0.32 |
| ▸ | TACR2 | P21452 | 4/20 | 0.32 |
| ▸ | TACR1 | P25103 | 4/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821209 | 0.90 | TACR3 (0.38) | TACR3GRM5MCHR1ALDH1A1HPGD | |
| SCHEMBL929503 | 0.88 | GRM5 (0.42) | TACR3GRM5MCHR1ALDH1A1HPGD | |
| SCHEMBL3818998 | 0.85 | TACR3 (0.40) | TACR3TACR2TACR1KCNH2CYP1A2 | |
| SCHEMBL3810312 | 0.85 | TACR3 (0.51) | TACR3TACR2TACR1KCNH2CYP1A2 | |
| SCHEMBL3822949 | 0.83 | P2RX7 (0.33) | TACR3GRM5TACR2TACR1ALDH1A1 | |
| SCHEMBL3819356 | 0.82 | TACR3 (0.37) | TACR3GRM5TACR2TACR1ALDH1A1 | |
| SCHEMBL929385 | 0.81 | ESR2 (0.47) | GRM5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3816782 | 0.81 | KLKB1 (0.39) | — | |
| SCHEMBL3812450 | 0.80 | QRFPR (0.37) | TACR3GRM5MCHR1 | |
| SCHEMBL3820174 | 0.80 | P2RX7 (0.42) | GRM5ALDH1A1HPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |