Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.79 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | EIF4E | P06730 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6498907 | 0.89 | ALDH1A1 (0.61) | HSD17B10CA1CA2SMN1; SMN2ALOX5 | |
| SCHEMBL7550083 | 0.89 | HSD17B10 (1.00) | HSD17B10CA1CA2SMN1; SMN2CA12 | |
| SCHEMBL29737473 | 0.89 | HSD17B10 (1.00) | HSD17B10CA1CA2SMN1; SMN2CA12 | |
| SCHEMBL699045 | 0.83 | HSD17B10 (0.81) | HSD17B10CA1CA2SMN1; SMN2CA12 | |
| SCHEMBL10079022 | 0.82 | HSD17B10 (0.79) | HSD17B10CA1CA2SMN1; SMN2CA12 | |
| SCHEMBL8339290 | 0.81 | MAPK1 (0.59) | HSD17B10MEN1MAPTKMT2ANPC1 | |
| SCHEMBL6499129 | 0.81 | HSD17B10 (0.51) | HSD17B10CA1CA2SMN1; SMN2EIF4E | |
| SCHEMBL6488777 | 0.81 | ANO1 (0.52) | HSD17B10CA1CA2SMN1; SMN2EIF4E | |
| SCHEMBL7262126 | 0.80 | HSD17B10 (0.76) | HSD17B10CA1CA2SMN1; SMN2CA12 | |
| SCHEMBL30013531 | 0.80 | HSD17B10 (0.76) | HSD17B10CA1CA2SMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953161-B1 | New tricyclic derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008110691-A1 | NOVEL TRICYCLIC DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2008-09-18 | — | — | WO | disclosed |
| EP-1953161-A1 | New tricyclic derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2008-08-06 | — | — | EP | disclosed |