Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TOP2A | P11388 | 3/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30906935 | 1.00 | KDM4E (0.59) | KDM4EPIK3CGPIK3CDPIK3R1PIK3CA | |
| SCHEMBL11114593 | 0.89 | KDM4E (0.59) | KDM4EPIK3CGPIK3CDPIK3R1PIK3CA | |
| Hydrochloric Acid SCHEMBL28898260 | 0.88 | KDM4E (0.57) | KDM4EPIK3CGPIK3CDPIK3R1PIK3CA | |
| SCHEMBL29576694 | 0.84 | KDM4E (0.59) | KDM4EPIK3CGPIK3CDPIK3R1PIK3CA | |
| SCHEMBL29541197 | 0.84 | KDM4E (0.59) | KDM4EPIK3CGPIK3CDPIK3R1PIK3CA | |
| SCHEMBL10595590 | 0.84 | KDM4E (0.59) | KDM4EPIK3CGPIK3CDPIK3R1PIK3CA | |
| SCHEMBL7118334 | 0.84 | KDM4E (0.59) | KDM4EPIK3CGPIK3CDPIK3R1PIK3CA | |
| SCHEMBL17897071 | 0.84 | KDM4E (0.59) | KDM4EPIK3CGPIK3CDPIK3R1PIK3CA | |
| SCHEMBL9146620 | 0.84 | KDM4E (0.59) | KDM4EPIK3CGPIK3CDPIK3R1PIK3CA | |
| SCHEMBL7578838 | 0.84 | KDM4E (0.59) | KDM4EPIK3CGPIK3CDPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756135-B1 | ESTER LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS | GLAXOSMITHKLINE ZAGREB (HR) | 2009-08-12 | — | — | EP | disclosed |
| US-20080255060-A1 | Ester Linked Macrolides Useful For The Treatment of Microbial Infections | GLAXOSMITHKLINE ISTRAZIVACKI CENTER ZAGREB (HR) | 2008-10-16 | — | — | US | disclosed |
| CN-101068824-A | Ester-linked macrolides for the treatment of microbial infections | GLAXOSMITHKLINE ZAGREB (HR) | 2007-11-07 | — | — | CN | disclosed |
| EP-1453846-B1 | 14 OR 15 MEMBERED MACROLIDES WITH ANTIBACTERIAL ACTIVITY | GLAXO GROUP LTD (GB) | 2007-05-16 | — | — | EP | disclosed |
| US-7202221-B2 | Macrolides | GLAXO GROUP LIMITED (GB) | 2007-04-10 | — | — | US | disclosed |
| CN-1307194-C | Macrolides | GLAXO GROUP LTD (GB) | 2007-03-28 | — | — | CN | disclosed |
| CN-1612888-A | Macrolides | GLAXO GROUP LTD (GB) | 2005-05-04 | — | — | CN | disclosed |
| US-20050080025-A1 | Macrolides | PLIVA D.D. (HR) | 2005-04-14 | — | — | US | disclosed |
| US-5457104-A | Antibacterials | BAYER AKTIENGESELLSCHAFT (DE) | 1995-10-10 | — | — | US | disclosed |
| CN-1097423-A | Quinolone-and naphthyridonecarboxylic acid derivatives | BAYER AG (DE) | 1995-01-18 | — | — | CN | disclosed |
| EP-0118854-B1 | BACTERICIDAL AGENT CONTAINING QUINOLONE-CARBOXYLIC ACIDS | BAYER AG (DE) | 1986-07-23 | — | — | EP | disclosed |
| US-4563459-A | FUNGICIDES AND BACTERICIDES FOR AGRICULTURAL USE | BAYER AKTIENGESELLSCHAFT (DE) | 1986-01-07 | — | — | US | disclosed |
| US-4563448-A | PHYTOPATHOGENS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-01-07 | — | — | US | disclosed |
| US-4559341-A | Quinolonecarboxylic acids and antibacterial agents containing these compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1985-12-17 | — | — | US | disclosed |
| US-4559342-A | Quinolone acids and antibacterial agents containing these compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1985-12-17 | — | — | US | disclosed |
| EP-0121727-A1 | Bactericidal agent based on quinolonecarboxylic acids | BAYER AG (DE) | 1984-10-17 | — | — | EP | disclosed |
| EP-0118854-A1 | Bactericidal agent containing quinolone-carboxylic acids | BAYER AG (DE) | 1984-09-19 | — | — | EP | disclosed |
| EP-0117474-A1 | Quinolone carboxylic acids, process for their preparation and antibacterial compositions containing them | BAYER AG (DE) | 1984-09-05 | — | — | EP | disclosed |
| EP-0117473-A1 | Quinolone carboxylic acids, process for their preparation and antibacterial compositions containing them | BAYER AG (DE) | 1984-09-05 | — | — | EP | disclosed |
| EP-0113091-A1 | Microbiocidal agents based on quinolone-carboxylic acids | BAYER AG (DE) | 1984-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255060-A1 | Ester Linked Macrolides Useful For The Treatment of Microbial Infections | CYP51A1, TLR5, MALT1 | KDM4E 2612/4885PIK3CG 3612/4885PIK3CD 3052/4885 |
| US-20050080025-A1 | Macrolides | IL17A, CYP51A1, IL15 | KDM4E 2733/4885PIK3CG 4596/4885PIK3CD 4329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.