Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.65 |
| ▸ | GSK3B | P49841 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28080833 | 0.91 | PTGS2 (0.69) | PTGS2GSK3BHPGDCYP2D6CYP2C9 | |
| SCHEMBL114611 | 0.87 | PTGS2 (0.67) | PTGS2GSK3B | |
| SCHEMBL9474080 | 0.84 | PTGS2 (0.64) | PTGS2GSK3B | |
| SCHEMBL9833136 | 0.84 | PTGS2 (0.47) | PTGS2GSK3BHPGDPOLBMEN1 | |
| SCHEMBL18049424 | 0.82 | PTGS2 (0.57) | PTGS2GSK3BHPGDNPC1RAB9A | |
| SCHEMBL1164429 | 0.81 | PTGS2 (0.58) | PTGS2GSK3BHPGDCYP2D6CYP2C9 | |
| SCHEMBL94149 | 0.81 | GSK3B (0.58) | PTGS2GSK3B | |
| SCHEMBL7778524 | 0.81 | GSK3B (0.78) | GSK3B | |
| SCHEMBL3819171 | 0.81 | GSK3B (0.51) | PTGS2GSK3BHPGDCYP2D6CYP2C9 | |
| SCHEMBL3816794 | 0.79 | GSK3B (0.67) | PTGS2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091531-A2 | PHENYL SUBSTITUTED MALEIMIDES AS MEDICAMENTS FOR BLOCKING DEGENERATIVE TISSUE DAMAGES BY INHIBITING MPT | Congenia S.r.l. (IT) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008067863-A2 | PHENYL SUBSTITUTED MALEIMIDES AS MEDICAMENTS FOR BLOCKING DEGENERATIVE TISSUE DAMAGES BY INHIBITING MPT | CONGENIA S.R.L. (IT) | 2008-06-12 | — | — | WO | disclosed |