Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.63 |
| ▸ | IGF1R | P08069 | 4/20 | 0.63 |
| ▸ | ERBB3 | P21860 | 4/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.63 |
| ▸ | NEK7 | Q8TDX7 | 12/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | SIK1 | P57059 | 1/20 | 0.45 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | DSTYK | Q6XUX3 | 1/20 | 0.45 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815384 | 1.00 | EGFR (0.63) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL4820107 | 0.87 | IGF1R (0.67) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL4820117 | 0.87 | IGF1R (0.67) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL4824623 | 0.87 | IGF1R (0.67) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL3816347 | 0.86 | EGFR (0.62) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6109590 | 0.82 | EGFR (0.75) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6109588 | 0.82 | EGFR (0.75) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6108958 | 0.80 | EGFR (0.82) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL3818589 | 0.80 | EGFR (0.82) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6867289 | 0.80 | EGFR (0.75) | EGFRERBB2IGF1RERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730148-A4 | AMINOBENZOXAZOLES AS THERAPEUTIC AGENTS | ABBOTT LAB (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1730148-A2 | AMINOBENZOXAZOLES AS THERAPEUTIC AGENTS | Abbott Laboratories (US) | 2006-12-13 | — | — | EP | disclosed |
| US-20060025383-A1 | Aminobenzoxazoles as therapeutic agents | ABBOTT LABORATORIES | 2006-02-02 | — | — | US | disclosed |
| WO-2005074603-A2 | AMINOBENZOXAZOLES AS THERAPEUTIC AGENTS | ABBOTT LABORATORIES (US) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025383-A1 | Aminobenzoxazoles as therapeutic agents | ABL1, MAP3K19, MAP3K20 | EGFR 506/4885ERBB2 47/4885IGF1R 2859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.