Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.31 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3812987 | 0.90 | DRD1 (0.37) | GRM5RIPK1HTTDRD1PARP1 | |
| SCHEMBL3817554 | 0.87 | GRM5 (0.33) | GRM5HTTHPGDDRD1KRAS | |
| SCHEMBL1010590 | 0.86 | GRM5 (0.51) | GRM5HPGD | |
| SCHEMBL3819392 | 0.84 | RIPK1 (0.46) | GRM5RIPK1HTTPARP1LMNA | |
| SCHEMBL3812215 | 0.84 | MAPK1 (0.35) | GRM5RIPK1GRIN2CHTTDRD1 | |
| SCHEMBL3817187 | 0.82 | MAPK1 (0.35) | GRM5RIPK1HTTKRASPARP1 | |
| SCHEMBL3815639 | 0.81 | TRPC3 (0.44) | GRM5RIPK1DRD1KRASPARP1 | |
| SCHEMBL3813334 | 0.81 | TRPC3 (0.44) | GRM5RIPK1DRD1KRASPARP1 | |
| SCHEMBL3816775 | 0.81 | TRPC3 (0.44) | GRM5RIPK1DRD1KRASPARP1 | |
| SCHEMBL3815429 | 0.80 | HTT (0.40) | GRM5GRIN2CHTTSMN1; SMN2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |