Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | TPH1 | P17752 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811707 | 0.94 | MEN1 (0.37) | MEN1KMT2AMAPTTMEM97SIGMAR1 | |
| SCHEMBL3816550 | 0.89 | TSHR (0.38) | MEN1KMT2AMAPTLMNAAKR1C3 | |
| SCHEMBL3814198 | 0.87 | PHGDH (0.42) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL1009688 | 0.86 | HPGD (0.43) | MAPTTMEM97SIGMAR1LMNAQRFPR | |
| SCHEMBL3820322 | 0.85 | KMT2A (0.38) | MEN1KMT2ADRD1LMNAAKR1C3 | |
| SCHEMBL3810544 | 0.84 | MEN1 (0.37) | MEN1KMT2ADRD1LMNA | |
| SCHEMBL3813746 | 0.84 | KLKB1 (0.35) | DRD1SMN1; SMN2LMNA | |
| SCHEMBL3821192 | 0.84 | HPGD (0.38) | MEN1KMT2AMAPTLMNAAKR1C3 | |
| SCHEMBL3811352 | 0.83 | KLKB1 (0.43) | — | |
| SCHEMBL3821156 | 0.83 | DRD1 (0.39) | MEN1KMT2AMAPTDRD1QRFPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |