Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 15/20 | 0.43 |
| ▸ | F11 | P03951 | 8/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817899 | 0.90 | KLKB1 (0.39) | KLKB1F11AKT1 | |
| SCHEMBL3813746 | 0.87 | KLKB1 (0.35) | KLKB1F11AKT1 | |
| SCHEMBL3813147 | 0.87 | F11 (0.40) | F11 | |
| SCHEMBL1009991 | 0.86 | KLKB1 (0.44) | KLKB1F11 | |
| SCHEMBL3820067 | 0.85 | DRD1 (0.42) | KLKB1F11 | |
| SCHEMBL3813529 | 0.84 | F11 (0.40) | KLKB1F11 | |
| SCHEMBL3815643 | 0.84 | MAPT (0.38) | — | |
| SCHEMBL3816988 | 0.83 | F11 (0.39) | KLKB1F11 | |
| SCHEMBL3815809 | 0.83 | MEN1 (0.37) | — | |
| SCHEMBL3818785 | 0.83 | DRD1 (0.36) | KLKB1F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |