Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 20/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011733 | 0.94 | GNRHR (0.83) | GNRHR | |
| SCHEMBL7009918 | 0.94 | GNRHR (0.82) | GNRHR | |
| SCHEMBL7006519 | 0.94 | GNRHR (0.82) | GNRHR | |
| Hydrochloric Acid SCHEMBL7012613 | 0.93 | GNRHR (0.81) | GNRHR | |
| SCHEMBL3821372 | 0.92 | GNRHR (0.80) | GNRHR | |
| SCHEMBL7010113 | 0.92 | GNRHR (1.00) | GNRHR | |
| Hydrochloric Acid SCHEMBL7498872 | 0.91 | GNRHR (0.98) | GNRHR | |
| SCHEMBL7497714 | 0.91 | GNRHR (0.71) | GNRHR | |
| SCHEMBL7005234 | 0.90 | GNRHR (0.77) | GNRHR | |
| SCHEMBL7100017 | 0.90 | GNRHR (0.79) | GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781774-B1 | Prolactin production inhibitory agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-07-31 | — | — | EP | claimed |
| EP-1520855-B1 | Thieno(2,3-b)pyridine derivatives useful as antagonists of gonadotropin releasing hormone | ORTHO MCNEIL JANSSEN PHARM (US) | 2009-12-02 | — | — | EP | disclosed |
| EP-1345907-B1 | 7-HETEROCYCLYL QUINOLINE AND THIENO 2,3-B|PYRIDINE DERIVATIVES USEFUL AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | ORTHO MCNEIL PHARM INC (US) | 2006-08-23 | — | — | EP | disclosed |
| EP-1520855-A1 | Thieno(2,3-b)pyridine derivatives useful as antagonists of gonadotropin releasing hormone | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6765011-B2 | ANTICANCER AGENTS; BEGNIN PROSTATE GLANDS; CONTRACEPTIVES | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-07-20 | — | — | US | disclosed |
| US-20030216429-A1 | 7-Heterocyclyl quinoline and thieno[2,3-b]pyridine derivatives useful as antagonists of gonadotropin releasing hormone | SUI ZHIHUA (US) | 2003-11-20 | — | — | US | disclosed |
| EP-1345907-A2 | 7-HETEROCYCLYL QUINOLINE AND THIENO 2,3-B]PYRIDINE DERIVATIVES USEFUL AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2003-09-24 | — | — | EP | disclosed |
| US-6583153-B2 | Treating infertility, prostate cancer and benign prostate hyperplasia (BPH) | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-06-24 | — | — | US | disclosed |
| US-20020123506-A1 | 7-Heterocyclyl quinoline and thieno(2,3-b)pyridine derivatives useful as antagonists of gonadotropin releasing hormone | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-09-05 | — | — | US | disclosed |
| WO-2002048112-A2 | 7-HETEROCYCLYL QUINOLINE AND THIENO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216429-A1 | 7-Heterocyclyl quinoline and thieno[2,3-b]pyridine derivatives useful as antagonists of gonadotropin releasing hormone | GNRHR, FSHR, LHCGR | GNRHR 1/4885 |
| US-20020123506-A1 | 7-Heterocyclyl quinoline and thieno(2,3-b)pyridine derivatives useful as antagonists of gonadotropin releasing hormone | GNRHR, FSHR, LHCGR | GNRHR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.