Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817543 | 1.00 | MAPT (0.48) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL1995568 | 0.75 | MAPT (0.57) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL1995570 | 0.75 | MAPT (0.57) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL2317675 | 0.73 | PTGS1 (0.57) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL28115197 | 0.72 | MAPT (0.53) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL28115196 | 0.72 | MAPT (0.53) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL30360229 | 0.70 | MAPT (0.55) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL15515688 | 0.69 | MAPT (0.53) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL23928529 | 0.68 | MAPT (0.64) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL27574325 | 0.67 | KMT2A (0.57) | MAPTSMN1; SMN2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2105436-A1 | Lactam-containing compounds and derivatives thereof as factor XA inhibitors | Bristol-Myers Squibb Company (US) | 2009-09-30 | — | — | EP | disclosed |
| EP-1427415-B1 | LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-08-12 | — | — | EP | disclosed |