Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3816843 | 0.94 | NR1H2 (0.36) | TDP1POLBNPC1RAB9AMAPT | |
| SCHEMBL3818191 | 0.89 | KDM4E (0.36) | TDP1POLBNPC1RAB9ANR1H2 | |
| SCHEMBL3819334 | 0.88 | NR1H2 (0.37) | TDP1POLBNPC1RAB9AMAPT | |
| SCHEMBL929668 | 0.86 | ALDH1A1 (0.51) | TDP1POLBSMN1; SMN2RAB9AMAPT | |
| SCHEMBL3817828 | 0.85 | NR1H2 (0.37) | TDP1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3816606 | 0.85 | HSD17B10 (0.36) | TDP1POLBNPC1RAB9AMAPT | |
| SCHEMBL3819246 | 0.83 | NR1H2 (0.36) | NPC1RAB9AMAPTNR1H2ALDH1A1 | |
| SCHEMBL3813232 | 0.81 | ALDH1A1 (0.40) | TDP1POLBNPC1RAB9AMAPT | |
| SCHEMBL3820007 | 0.81 | POLB (0.35) | NAMPTTDP1POLBSMN1; SMN2NPC1 | |
| SCHEMBL3820097 | 0.81 | ALDH1A1 (0.40) | TDP1POLBNPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |