Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.50 |
| ▸ | CD38 | P28907 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30344504 | 0.86 | MEN1 (0.61) | MEN1KMT2ATDP1MTNR1AMAPK8 | |
| SCHEMBL7134588 | 0.85 | TSHR (0.54) | MEN1KMT2ACYP3A4CYP2C19CYP2C9 | |
| SCHEMBL29154501 | 0.83 | CYP3A4 (0.56) | MEN1KMT2ACYP3A4CYP2C19CYP1A2 | |
| SCHEMBL28746958 | 0.81 | CYP3A4 (0.55) | MEN1KMT2ACYP3A4CYP2C19CYP1A2 | |
| SCHEMBL1128517 | 0.80 | CYP3A4 (0.54) | MEN1KMT2ACYP3A4CYP2C19CYP1A2 | |
| SCHEMBL29381201 | 0.79 | KDM4E (0.68) | MEN1KMT2ACYP3A4CYP2C19CYP1A2 | |
| SCHEMBL43084 | 0.79 | KDM4E (0.68) | MEN1KMT2ACYP3A4CYP2C19CYP1A2 | |
| SCHEMBL29154497 | 0.79 | CYP3A4 (0.56) | MEN1KMT2ACYP3A4CYP2C19CYP1A2 | |
| SCHEMBL599659 | 0.79 | CYP2C19 (0.62) | CYP3A4CYP2C19CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL29490353 | 0.79 | CYP2C19 (0.62) | CYP3A4CYP2C19CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-A2 | PYRIDO[2,3-B]PYRAZINE AND[1,8]-NAPHTYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2007130468-A2 | PYRIDO [2, 3-B] PYRAZINE AND [1, 8] -NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2007-11-15 | — | — | WO | disclosed |
| EP-1089966-A1 | NOVEL COMPOUNDS USEFUL IN PAIN MANAGEMENT | AstraZeneca AB (SE) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067205-A1 | NOVEL COMPOUNDS USEFUL IN PAIN MANAGEMENT | ASTRAZENECA AB (SE) | 1999-12-29 | — | — | WO | disclosed |