Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LHCGR | P22888 | 8/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819266 | 0.88 | KMT2A (0.44) | DRD1MAPK1NPSR1LHCGRKMT2A | |
| SCHEMBL3812051 | 0.84 | DRD1 (0.47) | DRD1MAPK1NPSR1LHCGRGRM5 | |
| SCHEMBL3818709 | 0.83 | DRD1 (0.51) | DRD1NPSR1KMT2AGRM5 | |
| SCHEMBL3820422 | 0.83 | DRD1 (0.51) | DRD1NPSR1KMT2AGRM5 | |
| SCHEMBL1868570 | 0.83 | GRM5 (0.56) | DRD1MAPK1NPSR1GRM5 | |
| SCHEMBL3815158 | 0.82 | GRM5 (0.43) | DRD1KMT2AGRM5HHAT | |
| SCHEMBL3818783 | 0.82 | OPRK1 (0.39) | DRD1MAPK1NPSR1KMT2A | |
| SCHEMBL3816705 | 0.81 | PARP1 (0.44) | DRD1MAPK1KMT2AGRM5 | |
| SCHEMBL3814049 | 0.79 | KMT2A (0.44) | DRD1MAPK1NPSR1LHCGRKMT2A | |
| SCHEMBL3819302 | 0.77 | GRM5 (0.40) | DRD1MAPK1KMT2AGRM5HHAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |