Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | FNTA | P49354 | 9/20 | 0.40 |
| ▸ | FNTB | P49356 | 9/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4193468 | 0.95 | GRM5 (0.42) | P2RX7FNTAFNTBGRM5 | |
| SCHEMBL3818045 | 0.88 | GRM5 (0.46) | P2RX7FNTAFNTBGRM5 | |
| SCHEMBL3824223 | 0.87 | DRD1 (0.49) | GRM5 | |
| SCHEMBL8012792 | 0.87 | DRD1 (0.49) | GRM5 | |
| SCHEMBL3812114 | 0.87 | DRD1 (0.49) | GRM5 | |
| SCHEMBL3813674 | 0.85 | P2RX7 (0.38) | P2RX7GRM5 | |
| SCHEMBL1010428 | 0.85 | GRM5 (0.49) | P2RX7FNTAFNTBGRM5 | |
| SCHEMBL3817228 | 0.85 | TRPC3 (0.42) | P2RX7GRM5 | |
| SCHEMBL3816607 | 0.83 | KMT2A (0.42) | P2RX7GRM5 | |
| SCHEMBL3820674 | 0.82 | P2RX7 (0.37) | P2RX7GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |