Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820193 | 0.93 | GRM5 (0.36) | GRM5CREBBP | |
| SCHEMBL3819321 | 0.89 | GRM5 (0.36) | GRM5CYP11B2CYP11B1 | |
| SCHEMBL3816597 | 0.89 | WDR5 (0.35) | CYP11B2CYP11B1WDR5 | |
| SCHEMBL3816668 | 0.88 | GRM5 (0.39) | GRM5 | |
| SCHEMBL3813124 | 0.87 | GRM5 (0.41) | GRM5 | |
| SCHEMBL928584 | 0.86 | GRM5 (0.52) | GRM5 | |
| SCHEMBL3812491 | 0.85 | NOTUM (0.39) | GRM5 | |
| SCHEMBL3822131 | 0.85 | GRM5 (0.40) | GRM5 | |
| SCHEMBL13720384 | 0.85 | NOTUM (0.40) | GRM5 | |
| SCHEMBL3821061 | 0.85 | NOTUM (0.40) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |