Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GFER | P55789 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHKA | P35790 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | NCF1 | P14598 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12294725 | 0.84 | HRH3 (0.48) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL13179270 | 0.84 | KDM4E (0.49) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL24422230 | 0.82 | CHKA (0.58) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL21933940 | 0.82 | ESR1 (0.42) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL13838188 | 0.79 | KDM4E (0.52) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL17876410 | 0.79 | ADRB1 (0.52) | MAPTGFERKDM4EGAASMN1; SMN2 | |
| SCHEMBL1476346 | 0.79 | MAPT (0.62) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL111714 | 0.79 | GAA (0.62) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL24422225 | 0.79 | CHKA (0.44) | MAPTCHKACTSLCTSBCTSS | |
| SCHEMBL4544738 | 0.77 | ADRB1 (0.53) | MAPTSMN1; SMN2ALDH1A1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129675-A2 | DERIVATIVES OF IMIDAZO, PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | IPSEN PHARMA S.A.S. (FR) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008090286-A2 | DERIVATIVES OF IMIDAZO, PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG | IPSEN PHARMA S.A.S. (FR) | 2008-07-31 | — | — | WO | disclosed |