Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14180351 | 0.80 | ALDH3A1 (0.40) | ALDH3A1ARMAOBTSHRMAP4K4 | |
| SCHEMBL6012103 | 0.80 | MAOB (0.44) | ARMAOBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL6174449 | 0.80 | SLC6A2 (0.50) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL15670707 | 0.79 | MAOB (0.40) | HTR2ASLC6A4ARMAOBCYP2C9 | |
| Hydrochloric Acid SCHEMBL7868631 | 0.78 | SLC6A2 (0.48) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL7691770 | 0.75 | MAPT (0.55) | ARL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL799930 | 0.75 | MAOB (0.42) | HTR2AMAOBTSHRMAP4K4CYP1A2 | |
| SCHEMBL6012077 | 0.74 | ALDH3A1 (0.38) | ALDH3A1HTR2AARTSHRL3MBTL1 | |
| SCHEMBL6390343 | 0.72 | SLC6A4 (0.44) | SLC6A2SLC6A4SLC6A3ARMAPT | |
| SCHEMBL10636671 | 0.72 | MEN1 (0.45) | HTR2AMAOBTSHRMAP4K4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7063856-B2 | Pharmaceutical composition containing aminocetonitrile compounds and the use thereof for the preparation of a pharmaceutical composition for the treatment of endoparasitic pests in animals | NOVARTIS ANIMAL HEALTH US, INC. (US) | 2006-06-20 | — | — | US | claimed |
| US-10391076-B2 | Anti-cancer agent comprising aminoacetonitrile compound as active ingredient | PITNEY PHARMACEUTICALS PTY LTD. (AU) | 2019-08-27 | — | — | US | disclosed |
| US-10292960-B2 | Anticancer agent comprising aminoacetonitrile compound as active ingredient | PITNEY PHARMACEUTICALS PTY LIMITED (AU) | 2019-05-21 | — | — | US | disclosed |
| EP-3043791-B1 | ANTICANCER AGENT COMPRISING AMINOACETONITRILE COMPOUND AS ACTIVE INGREDIENT | PITNEY PHARMACEUTICALS PTY LTD (AU) | 2019-04-24 | — | — | EP | disclosed |
| US-20180243255-A1 | ANTI-CANCER AGENT COMPRISING AMINOACETONITRILE COMPOUND AS ACTIVE INGREDIENT | PITNEY PHARMACEUTICALS PTY LIMITED (AU) | 2018-08-30 | — | — | US | disclosed |
| US-20180207124-A1 | ANTICANCER AGENT COMPRISING AMINOACETONITRILE COMPOUND AS ACTIVE INGREDIENT | PITNEY PHARMACEUTICALS PTY LIMITED (AU) | 2018-07-26 | — | — | US | disclosed |
| US-9907778-B2 | Anticancer agent comprising aminoacetonitrile compound as active ingredient | PITNEY PHARMACEUTICALS PTY LIMITED (AU) | 2018-03-06 | — | — | US | disclosed |
| US-20160213640-A1 | ANTICANCER AGENT COMPRISING AMINOACETONITRILE COMPOUND AS ACTIVE INGREDIENT | NIHON NOHYAKU CO., LTD. (JP) | 2016-07-28 | — | — | US | disclosed |
| EP-1513802-B1 | ALPHA-SULFONYLAMINO-ACETONITRILES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| US-7368479-B2 | Alpha-sulfonylamino-acetonitriles | SYNGENTA CROP PROTECTION, INC. (US) | 2008-05-06 | — | — | US | disclosed |
| US-20050234125-A1 | Alpha-sulfonylamino-acetonitriles | SYNGENTA CROP PROTECTION AG (CH) | 2005-10-20 | — | — | US | disclosed |
| EP-1513802-A1 | ALPHA-SULFONYLAMINO-ACETONITRILES | Syngenta Participations AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| EP-1445251-A9 | Aminoacetonitrile derivative, agricultural and horticultural insecticide containing the same, and use thereof | NIHON NOHYAKU CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| EP-0953565-B1 | Aminoacetonitrile derivative, agricultural and horticultural insecticide containing the same, and use thereof | NIHON NOHYAKU CO LTD (JP) | 2004-09-08 | — | — | EP | disclosed |
| EP-1445251-A1 | Aminoacetonitrile derivative, agricultural and horticultural insecticitde containing the same, and use thereof | NIHON NOHYAKU CO., LTD. (JP) | 2004-08-11 | — | — | EP | disclosed |
| WO-2004000797-A1 | ALPHA-SULFONYLAMINO-ACETONITRILES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-12-31 | — | — | WO | disclosed |
| CN-1132516-C | Amino-acetonitrile derivative, pesticides containing same for farm and gardening and use thereof | NIHON NOHYAKU CO LTD (JP) | 2003-12-31 | — | — | CN | disclosed |
| US-6239077-B1 | PESTICIDES; APPLYING TO PLANTS | NIHON NOHYAKU CO., LTD. (JP) | 2001-05-29 | — | — | US | disclosed |
| CN-1234177-A | Amino-acetonitrile derivative, pesticides containing same for farm and gardening and use thereof | NIHON NOHYAKU CO LTD (JP) | 1999-11-10 | — | — | CN | disclosed |
| EP-0953565-A2 | Aminoacetonitrile derivative, agricultural and horticultural insecticide containing the same, and use thereof | NIHON NOHYAKU CO., LTD. (JP) | 1999-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10391076-B2 | Anti-cancer agent comprising aminoacetonitrile compound as active ingredient | RB1, CCNA1, CCNT1 | ALDH3A1 834/4885SLC6A2 2699/4885HTR2A 3038/4885 |
| US-20050234125-A1 | Alpha-sulfonylamino-acetonitriles | C3AR1, C1S, C5 | ALDH3A1 1660/4885SLC6A2 3047/4885HTR2A 1232/4885 |
| US-10292960-B2 | Anticancer agent comprising aminoacetonitrile compound as active ingredient | RB1, CCNA1, NAT1 | ALDH3A1 743/4885SLC6A2 2340/4885HTR2A 2475/4885 |
| US-20160213640-A1 | ANTICANCER AGENT COMPRISING AMINOACETONITRILE COMPOUND AS ACTIVE INGREDIENT | RB1, CCNA1, NAT1 | ALDH3A1 743/4885SLC6A2 2340/4885HTR2A 2475/4885 |
| US-20180243255-A1 | ANTI-CANCER AGENT COMPRISING AMINOACETONITRILE COMPOUND AS ACTIVE INGREDIENT | RB1, CCNA1, CCNT1 | ALDH3A1 834/4885SLC6A2 2699/4885HTR2A 3038/4885 |
| US-20180207124-A1 | ANTICANCER AGENT COMPRISING AMINOACETONITRILE COMPOUND AS ACTIVE INGREDIENT | RB1, CCNA1, NAT1 | ALDH3A1 743/4885SLC6A2 2340/4885HTR2A 2475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.