Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3812884 | 0.89 | GAA (0.34) | LMNASMN1; SMN2HTTNCOA1NCOA3 | |
| SCHEMBL13720273 | 0.89 | HTT (0.33) | SMN1; SMN2HTTNCOA1NCOA3ALDH1A1 | |
| SCHEMBL3817567 | 0.88 | SMN1; SMN2 (0.39) | LMNACYP1A2CYP2C19SMN1; SMN2HTT | |
| SCHEMBL1010407 | 0.86 | ALDH1A1 (0.48) | GRM5ALDH1A1MAPTGAATDP1 | |
| SCHEMBL3815122 | 0.80 | HTT (0.47) | LMNACYP1A2CYP2C19SMN1; SMN2HTT | |
| SCHEMBL3816475 | 0.80 | HTT (0.45) | LMNACYP1A2CYP2C19SMN1; SMN2HTT | |
| SCHEMBL3812171 | 0.79 | GRM5 (0.38) | LMNASMN1; SMN2HTTGRM5MAPK1 | |
| SCHEMBL3819045 | 0.79 | GRM5 (0.36) | LMNAHTTGRM5MAPK1ALDH1A1 | |
| SCHEMBL3815351 | 0.79 | GRM5 (0.38) | GRM5ALDH1A1MAPTGAATDP1 | |
| SCHEMBL1011505 | 0.79 | GRM5 (0.43) | LMNAGRM5ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |