Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821033 | 0.90 | MAPT (0.35) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL3819952 | 0.89 | MAPT (0.34) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL3816915 | 0.88 | KDM4E (0.35) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL3820926 | 0.88 | MAPT (0.34) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL3820007 | 0.86 | POLB (0.35) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL929942 | 0.86 | TDP1 (0.48) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL3811828 | 0.84 | ALDH1A1 (0.39) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL3816652 | 0.83 | ALDH1A1 (0.51) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL3821005 | 0.82 | ALDH1A1 (0.38) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL3817828 | 0.80 | NR1H2 (0.37) | ALDH1A1MAPTGAAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |