Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 5/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3818996 | 0.87 | CFTR (0.63) | CFTRPKMLMNAGBA1HSD11B1 | |
| SCHEMBL6341359 | 0.84 | CFTR (0.59) | CFTRPKMLMNAGBA1HSD11B1 | |
| SCHEMBL3820111 | 0.83 | CFTR (0.64) | CFTRPKMLMNAGBA1HSD11B1 | |
| SCHEMBL3824104 | 0.82 | CFTR (0.80) | CFTRPKMLMNAGBA1HSD11B1 | |
| SCHEMBL15457218 | 0.82 | CFTR (0.68) | CFTRPKMLMNAGBA1HSD11B1 | |
| SCHEMBL3816483 | 0.82 | CFTR (0.70) | CFTRPKMLMNAGBA1HSD11B1 | |
| SCHEMBL3824055 | 0.82 | CFTR (0.70) | CFTRPKMLMNAGBA1HSD11B1 | |
| SCHEMBL3824113 | 0.81 | CFTR (0.65) | CFTRPKMLMNAGBA1HSD11B1 | |
| SCHEMBL3820105 | 0.81 | CFTR (0.62) | CFTRPKMLMNAGBA1HSD11B1 | |
| SCHEMBL3820417 | 0.80 | CFTR (0.66) | CFTRPKMLMNAGBA1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642609-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-02-04 | — | — | US | disclosed |
| EP-1646615-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2009-08-26 | — | — | EP | disclosed |
| US-20050059687-A1 | Modulators of ATP-Binding Cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059687-A1 | Modulators of ATP-Binding Cassette transporters | CFTR, ABCB1, ABCC2 | CFTR 1/4885PKM 2518/4885LMNA 3024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.