Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.31 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.31 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.30 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.30 |
| ▸ | OGG1 | O15527 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846221 | 0.92 | P2RX3 (0.66) | P2RX3ALDH1A1RENADAMTS4ADAMTS5 | |
| SCHEMBL3817692 | 0.88 | P2RX3 (0.67) | P2RX3ALDH1A1RENADAMTS4ADAMTS5 | |
| SCHEMBL3811300 | 0.86 | P2RX3 (0.55) | P2RX3ALDH1A1GAAMAPTMBTPS1 | |
| SCHEMBL3819413 | 0.85 | P2RX3 (0.45) | P2RX3ALDH1A1DAPK1PIM3MAPT | |
| SCHEMBL3822470 | 0.80 | P2RX3 (0.63) | P2RX3ALDH1A1RENADAMTS4ADAMTS5 | |
| SCHEMBL3820917 | 0.79 | P2RX3 (0.62) | P2RX3ALDH1A1RENADAMTS4ADAMTS5 | |
| SCHEMBL1305720 | 0.79 | P2RX3 (0.70) | P2RX3ALDH1A1ADAMTS4ADAMTS5DAPK1 | |
| SCHEMBL1305722 | 0.79 | P2RX3 (0.69) | P2RX3ALDH1A1ADAMTS4ADAMTS5DAPK1 | |
| SCHEMBL1305717 | 0.79 | P2RX3 (0.69) | P2RX3ALDH1A1ADAMTS4ADAMTS5DAPK1 | |
| SCHEMBL1307193 | 0.78 | P2RX3 (0.67) | P2RX3ALDH1A1ADAMTS4ADAMTS5DAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089354-A1 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Korea Research Institute Of Chemical Technology (KR) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008054154-A1 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-05-08 | — | — | WO | disclosed |