Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22509747 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22131673 | 0.77 | ALDH1A1 (0.44) | ALDH1A1PRMT5WDR77NPC1RAB9A | |
| SCHEMBL22521396 | 0.76 | ALDH1A1 (0.43) | ALDH1A1PRMT5WDR77KDRNPC1 | |
| SCHEMBL22509851 | 0.76 | ACACB (0.44) | ALDH1A1FLT4KDR | |
| SCHEMBL27966117 | 0.73 | ALDH1A1 (0.41) | ALDH1A1PRMT5WDR77NPC1RAB9A | |
| SCHEMBL19692054 | 0.73 | ALDH1A1 (0.58) | ALDH1A1FLT4KDRNPC1RAB9A | |
| SCHEMBL20971298 | 0.73 | ALDH1A1 (0.44) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL18572036 | 0.72 | SLC22A12 (0.48) | ALDH1A1PRMT5WDR77SMN1; SMN2MAPT | |
| SCHEMBL23892409 | 0.70 | PRMT5 (0.37) | ALDH1A1PRMT5WDR77NPC1RAB9A | |
| SCHEMBL22131933 | 0.70 | ACACB (0.51) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |
| WO-2009143018-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2009-11-26 | — | — | WO | disclosed |