Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821461 | 0.97 | LMNA (0.59) | LMNAADKRAB9AHPGDNPC1 | |
| SCHEMBL3817191 | 0.95 | LMNA (0.51) | LMNAADKRAB9AHPGDNPC1 | |
| SCHEMBL8193927 | 0.92 | LMNA (0.49) | LMNAADKSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7205814 | 0.92 | LMNA (0.49) | LMNAADKSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7209654 | 0.92 | LMNA (0.49) | LMNAADKSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8193747 | 0.92 | LMNA (0.49) | LMNAADKSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3817265 | 0.91 | LMNA (0.46) | LMNAADKSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7204782 | 0.91 | LMNA (0.47) | LMNAADKSMN1; SMN2THRBHIF1A | |
| SCHEMBL8196905 | 0.91 | LMNA (0.47) | LMNAADKSMN1; SMN2THRBHIF1A | |
| SCHEMBL8192678 | 0.90 | LMNA (0.47) | LMNAADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882734-B1 | 5'-Deoxy-cytidine derivatives | HOFFMANN LA ROCHE (CH) | 2009-08-26 | — | — | EP | disclosed |
| US-6211166-B1 | COADMINISTERED WITH A 5-FLUOROURACIL DERIVATIVE; ANTICARCINOGENIC AGENTS | HOFFMAN-LA ROCHE INC. | 2001-04-03 | — | — | US | disclosed |
| EP-0882734-A2 | 5'-Deoxy-cytidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-09 | — | — | EP | disclosed |