Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ADK | P55263 | 8/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819094 | 1.00 | LMNA (0.58) | LMNAADKTSHRMAPTPMP22 | |
| SCHEMBL7205842 | 0.92 | LMNA (0.56) | LMNAADKTSHRMAPTPMP22 | |
| SCHEMBL8193930 | 0.92 | LMNA (0.56) | LMNAADKTSHRMAPTPMP22 | |
| SCHEMBL3819090 | 0.91 | LMNA (0.55) | LMNAADKTSHRMAPTPMP22 | |
| SCHEMBL3824606 | 0.91 | LMNA (0.55) | LMNAADKTSHRMAPTPMP22 | |
| SCHEMBL3820963 | 0.90 | LMNA (0.66) | LMNAADKTSHRMAPTPMP22 | |
| SCHEMBL8198722 | 0.89 | LMNA (0.60) | LMNAADKTSHRMAPTPMP22 | |
| SCHEMBL7205091 | 0.89 | LMNA (0.60) | LMNAADKTSHRMAPTPMP22 | |
| SCHEMBL3825870 | 0.88 | LMNA (0.60) | LMNAADKTSHRMAPTPMP22 | |
| SCHEMBL7209579 | 0.88 | LMNA (0.58) | LMNAADKTSHRMAPTPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882734-B1 | 5'-Deoxy-cytidine derivatives | HOFFMANN LA ROCHE (CH) | 2009-08-26 | — | — | EP | disclosed |
| US-6211166-B1 | COADMINISTERED WITH A 5-FLUOROURACIL DERIVATIVE; ANTICARCINOGENIC AGENTS | HOFFMAN-LA ROCHE INC. | 2001-04-03 | — | — | US | disclosed |
| US-6114520-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0882734-A2 | 5'-Deoxy-cytidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-09 | — | — | EP | disclosed |