Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3237518 | 0.83 | CYP46A1 (0.46) | CYP46A1SMN1; SMN2SPRGRIN2DGRIN3B | |
| SCHEMBL3236551 | 0.81 | CYP46A1 (0.40) | CYP46A1SPRGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3232554 | 0.81 | MEN1 (0.41) | ALDH1A1CYP46A1SMN1; SMN2SPRGRIN2D | |
| SCHEMBL3232447 | 0.81 | L3MBTL1 (0.40) | ALDH1A1CYP46A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL3240308 | 0.80 | CYP46A1 (0.41) | ALDH1A1CYP46A1SMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL3244022 | 0.79 | CYP46A1 (0.41) | CYP46A1SMN1; SMN2SPRGRIN2DGRIN3B | |
| SCHEMBL3247535 | 0.79 | GAA (0.43) | ALDH1A1CYP46A1KDM4ESMN1; SMN2 | |
| SCHEMBL8018991 | 0.77 | L3MBTL1 (0.41) | ALDH1A1CYP46A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL3240073 | 0.77 | CYP46A1 (0.48) | CYP46A1SMN1; SMN2SPRGRIN2DGRIN3B | |
| SCHEMBL3242158 | 0.75 | CYP46A1 (0.42) | CYP46A1SMN1; SMN2SPRGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009131952-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING THIAZOLE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2009-10-29 | — | — | WO | claimed |