Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.47 |
| ▸ | ITGAV | P06756 | 8/20 | 0.47 |
| ▸ | CASR | P41180 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382991 | 0.90 | ITGB3 (0.47) | ITGB3ITGA2BITGAVCASRKCNH2 | |
| SCHEMBL382384 | 0.86 | ITGB3 (0.65) | ITGB3ITGA2BITGAV | |
| SCHEMBL383120 | 0.86 | ITGB3 (0.43) | ITGB3ITGA2BITGAVCASRKCNH2 | |
| SCHEMBL27551456 | 0.86 | ITGB3 (0.51) | ITGB3ITGA2BITGAVCASRITGB1 | |
| SCHEMBL382764 | 0.86 | ITGB3 (0.51) | ITGB3ITGA2BITGAVCASRITGB1 | |
| SCHEMBL382427 | 0.85 | ITGB3 (0.43) | ITGB3ITGA2BITGAVKCNH2MMP3 | |
| SCHEMBL382319 | 0.84 | MAPT (0.47) | ITGB3ITGA2BITGAV | |
| SCHEMBL460323 | 0.83 | ITGB3 (0.41) | ITGB3ITGA2BITGAVCASRKCNH2 | |
| SCHEMBL382937 | 0.81 | ITGB3 (0.66) | ITGB3ITGA2BITGAVCASRMMP3 | |
| SCHEMBL7655429 | 0.80 | ITGB3 (0.44) | ITGB3ITGA2BITGAVCASRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | claimed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | claimed |
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| CN-1140511-C | As integrin alphavβ3Aminopiperidine derivatives as antagonists | �����Ƹ���ʽ���� | 2004-03-03 | — | — | CN | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |