Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171194 | 1.00 | BACE1 (0.54) | BACE1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL6170385 | 0.90 | PTGS2 (0.49) | BACE1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL6170382 | 0.90 | PTGS2 (0.49) | BACE1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL30100696 | 0.90 | PTGS2 (0.49) | BACE1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL1028988 | 0.86 | STAT3 (0.54) | BACE1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL1028987 | 0.86 | STAT3 (0.54) | BACE1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL6170004 | 0.86 | BACE1 (0.54) | BACE1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL6169997 | 0.86 | BACE1 (0.54) | BACE1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL6170179 | 0.84 | BACE1 (0.62) | BACE1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL6172741 | 0.84 | BACE1 (0.68) | BACE1MAPTLMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49698-E1 | Substituted dihydroquinazolines | AIC246 AG & CO. KG (DE) | 2023-10-17 | — | — | US | disclosed |
| US-RE49698-E1 | Substituted dihydroquinazolines | AIC246 AG & CO. KG (DE) | 2023-10-17 | — | — | US | disclosed |
| US-RE49698-E1 | Substituted dihydroquinazolines | AIC246 AG & CO. KG (DE) | 2023-10-17 | — | — | US | disclosed |
| EP-1622880-B3 | SUBSTITUTED DIHYDROCHINAZOLINES HAVING ANTIVIRAL PROPERTIES | AICURIS ANTI INFECTIVE CURES GMBH (DE) | 2018-05-23 | — | — | EP | disclosed |
| EP-1622880-B3 | SUBSTITUTED DIHYDROCHINAZOLINES HAVING ANTIVIRAL PROPERTIES | AICURIS ANTI INFECTIVE CURES GMBH (DE) | 2018-05-23 | — | — | EP | disclosed |
| US-RE46791-E1 | Substituted dihydroquinazolines | AICURIS ANTI-INFECTIVE CURES GMBH (DE) | 2018-04-17 | — | — | US | disclosed |
| US-RE46791-E1 | Substituted dihydroquinazolines | AICURIS ANTI-INFECTIVE CURES GMBH (DE) | 2018-04-17 | — | — | US | disclosed |
| US-8513255-B2 | Substituted dihydroquinazolines | AiCuris GmbH + Co. KG. (DE) | 2013-08-20 | — | — | US | disclosed |
| US-8513255-B2 | Substituted dihydroquinazolines | AiCuris GmbH + Co. KG. (DE) | 2013-08-20 | — | — | US | disclosed |
| US-8343981-B2 | Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents | AICURIS GMBH & CO. KG (DE) | 2013-01-01 | — | — | US | disclosed |
| EP-1622880-B1 | SUBSTITUTED DIHYDROCHINAZOLINES HAVING ANTIVIRAL PROPERTIES | BAYER HEALTHCARE AG (DE) | 2007-02-28 | — | — | EP | disclosed |
| EP-1685123-A2 | SUBSTITUTED DIHYDROQUINAZOLINES II | Bayer HealthCare AG (DE) | 2006-08-02 | — | — | EP | disclosed |
| EP-1625129-A1 | HETEROCYCLYL-SUBSTITUTED DIHYDROQUINAZOLINES AND USE THEREOF AS AN ANTIVIRAL AGENT | Bayer HealthCare AG (DE) | 2006-02-15 | — | — | EP | disclosed |
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| WO-2005047278-A2 | SUBSTITUTED DIHYDROQUINAZOLINES II | BAYER HEALTHCARE AG (DE) | 2005-05-26 | — | — | WO | disclosed |
| WO-2004099212-A1 | HETEROCYCLYL-SUBSTITUTED DIHYDROQUINAZOLINES AND USE THEREOF AS AN ANTIVIRAL AGENT | BAYER HEALTHCARE AG (DE) | 2004-11-18 | — | — | WO | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1065206-B1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER (US) | 2002-10-09 | — | — | EP | disclosed |
| CN-1284064-A | 2,3-substituted indole compounds as cox-2 inhibitors | PFIZER PHARMA (US) | 2001-02-14 | — | — | CN | disclosed |
| EP-1065206-A1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER INC. (US) | 2001-01-03 | — | — | EP | disclosed |