Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1333775 | 0.95 | HTR1A (0.48) | HTR1ASLC6A4ABCB1ACHEBACE1 | |
| SCHEMBL1332119 | 0.93 | HTR1A (0.51) | HTR1ASLC6A4ABCB1L3MBTL1ACHE | |
| SCHEMBL1332112 | 0.84 | HTR1A (0.52) | HTR1ASLC6A4ABCB1ACHEBACE1 | |
| SCHEMBL2574419 | 0.84 | HTR1A (0.52) | HTR1ASLC6A4ABCB1ACHEBACE1 | |
| SCHEMBL1333914 | 0.84 | HTR1A (0.59) | HTR1ASLC6A4ABCB1GAAMAPT | |
| SCHEMBL1332009 | 0.84 | HTR1A (0.52) | HTR1ASLC6A4ABCB1 | |
| SCHEMBL1334374 | 0.83 | HTR1A (0.49) | HTR1ASLC6A4ABCB1ACHEBACE1 | |
| SCHEMBL2573352 | 0.83 | HTR1A (0.49) | HTR1ASLC6A4ABCB1ACHEBACE1 | |
| SCHEMBL1334517 | 0.83 | ABCB1 (0.60) | HTR1ASLC6A4ABCB1ACHEBACE1 | |
| SCHEMBL1332760 | 0.82 | HTR1A (0.50) | HTR1ASLC6A4ABCB1ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1978959-A4 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2009-09-02 | — | — | EP | disclosed |
| EP-1978959-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008096189-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2008-08-14 | — | — | WO | disclosed |