Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA6 | P23280 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3726302 | 1.00 | PTPN1 (0.45) | PTPN1KMT2AMEN1CA12CA2 | |
| SCHEMBL15046544 | 0.86 | MEN1 (0.44) | PTPN1KMT2AMEN1CA12CA2 | |
| SCHEMBL12571594 | 0.85 | MAPT (0.47) | KMT2AMEN1KDM4ESMN1; SMN2GAA | |
| SCHEMBL5792614 | 0.85 | LCK (0.43) | KDM4ESMN1; SMN2POLBMAPTL3MBTL1 | |
| SCHEMBL1285843 | 0.81 | ALOX15 (0.49) | KMT2AMEN1CA12CA2CA9 | |
| SCHEMBL1285549 | 0.77 | CA12 (0.48) | KMT2AMEN1CA12CA2CA9 | |
| SCHEMBL909883 | 0.77 | CA12 (0.40) | KMT2AMEN1CA12CA2CA9 | |
| SCHEMBL4980048 | 0.77 | KMT2A (0.51) | KMT2AMEN1KDM4ESMN1; SMN2GAA | |
| SCHEMBL4864106 | 0.77 | ATM (0.44) | PTPN1KMT2AMEN1CA12CA2 | |
| SCHEMBL12275774 | 0.71 | ATM (0.41) | CA2CA9CA1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091944-A2 | SUBSTITUTED BICYCLOCARBOXYAMIDE COMPOUNDS | Pfizer, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008059370-A2 | SUBSTITUTED BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER JAPAN INC. (JP) | 2008-05-22 | — | — | WO | disclosed |