Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 14/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3460009 | 0.88 | KDM4E (0.51) | ATRTYRO3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL3461745 | 0.83 | KDM4E (0.58) | ATRTYRO3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL3460080 | 0.82 | TYRO3 (0.60) | ATRTYRO3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL3462291 | 0.80 | LDHA (0.58) | ATRTYRO3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL3460033 | 0.80 | ATR (0.53) | ATRTYRO3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL3460077 | 0.80 | TYRO3 (0.57) | ATRTYRO3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL3461524 | 0.78 | PIK3CD (0.61) | ATRPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL3460396 | 0.78 | HDAC3 (0.58) | ATRTYRO3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL3461225 | 0.78 | TYRO3 (0.70) | ATRTYRO3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL3462690 | 0.77 | TYRO3 (0.71) | ATRTYRO3PIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |