Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3068986 | 0.89 | AR (0.57) | ARNPC1RAB9ATP53MAPT | |
| SCHEMBL3822048 | 0.79 | PIK3CD (0.55) | ARNPC1RAB9AMAPTLMNA | |
| SCHEMBL4735786 | 0.77 | AR (0.43) | ARNPC1RAB9ATP53LMNA | |
| SCHEMBL3053954 | 0.76 | LMNA (0.44) | ARNPC1RAB9ATP53LMNA | |
| Hydrochloric Acid SCHEMBL3054076 | 0.75 | LMNA (0.43) | ARNPC1RAB9ATP53LMNA | |
| Hydrochloric Acid SCHEMBL4739170 | 0.75 | LMNA (0.43) | ARNPC1RAB9ATP53LMNA | |
| SCHEMBL28003487 | 0.74 | MAPT (0.53) | ARNPC1RAB9AMAPTLMNA | |
| SCHEMBL17014765 | 0.72 | AR (1.00) | ARNPC1RAB9AMAPTLMNA | |
| SCHEMBL3068984 | 0.72 | NPC1 (0.55) | ARNPC1RAB9ALMNAHTT | |
| SCHEMBL3053506 | 0.71 | AR (0.46) | ARNPC1RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-2091917-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |