Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 4/20 | 0.32 |
| ▸ | BTK | Q06187 | 3/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | TXK | P42681 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 3/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2066820 | 0.79 | NTRK1 (0.41) | NTRK1ITK | |
| SCHEMBL3827871 | 0.71 | NTRK1 (0.38) | NTRK1JAK3BTKITK | |
| SCHEMBL3832197 | 0.70 | NTRK1 (0.45) | NTRK1JAK3BTKTXK | |
| SCHEMBL2066392 | 0.70 | NTRK1 (0.41) | NTRK1ITK | |
| SCHEMBL14144927 | 0.69 | NTRK1 (0.40) | NTRK1ITKCDK2 | |
| SCHEMBL2067753 | 0.69 | JAK3 (0.34) | NTRK1JAK3BTKTXKITK | |
| SCHEMBL2065567 | 0.68 | NTRK1 (0.41) | NTRK1ITKCDK2 | |
| SCHEMBL3832186 | 0.68 | NTRK1 (0.47) | NTRK1JAK3BTKTXKITK | |
| SCHEMBL3827914 | 0.68 | NTRK1 (0.51) | NTRK1JAK3BTKTXKITK | |
| SCHEMBL2066184 | 0.67 | NTRK1 (0.41) | NTRK1ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099794-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008079873-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-03 | — | — | WO | disclosed |