Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 12/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | SIK1 | P57059 | 1/20 | 0.43 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.43 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825279 | 0.83 | IDH2 (0.56) | IDH2GPR35 | |
| SCHEMBL5106389 | 0.81 | KDM4E (0.53) | NPC1SMN1; SMN2 | |
| SCHEMBL3846891 | 0.79 | IDH2 (0.51) | IDH2 | |
| SCHEMBL3827067 | 0.79 | IDH2 (0.52) | IDH2 | |
| SCHEMBL5991829 | 0.76 | MAOB (0.52) | MAOBMAOASIK1SIK2SIK3 | |
| SCHEMBL3831632 | 0.75 | HCRTR1 (0.49) | IDH2 | |
| SCHEMBL3831610 | 0.74 | P2RY14 (0.46) | IDH2GPR35SMN1; SMN2 | |
| SCHEMBL10179873 | 0.74 | MCHR1 (0.42) | — | |
| SCHEMBL10762758 | 0.73 | SIK1 (0.60) | MAOBMAOASIK1SIK2SIK3 | |
| SCHEMBL5106415 | 0.73 | MAPT (0.51) | NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765339-A4 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2009-09-02 | — | — | EP | claimed |
| EP-1765339-A2 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-03-28 | — | — | EP | claimed |
| WO-2006005057-A2 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2006-01-12 | — | — | WO | claimed |