Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825490 | 0.89 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL3822946 | 0.83 | PTGS2 (0.87) | PTGS2PTGS1 | |
| SCHEMBL8654073 | 0.83 | PTGS2 (0.78) | PTGS2PTGS1 | |
| SCHEMBL220107 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL3822242 | 0.82 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL3821537 | 0.82 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL3820828 | 0.81 | PTGS2 (0.77) | PTGS2PTGS1 | |
| SCHEMBL3828986 | 0.81 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL3821955 | 0.80 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL3824545 | 0.80 | PTGS2 (0.78) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097385-A1 | 2-[1-PHENYL-5-HYDROXY OR METHOXY-4ALPHA-METHYL-HEXAHYDROCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS | Merck & Co., Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-1758852-B1 | SUBSTITUTED CYCLOPENTENE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008051532-A1 | 2-[1-PHENYL-5-HYDROXY OR METHOXY-4ALPHA-METHYL-HEXAHYDROCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS | MERCK & CO., INC. (US) | 2008-05-02 | — | — | WO | disclosed |
| US-7109214-B2 | Substituted cyclopentene compounds | GRUNENTHAL GMBH (DE) | 2006-09-19 | — | — | US | disclosed |
| US-20050272955-A1 | Substituted cyclopentene compounds | GRUNENTHAL GMBH (DE) | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272955-A1 | Substituted cyclopentene compounds | SQLE, CYP3A5, CYP2F1 | PTGS2 306/4885PTGS1 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.