Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.54 |
| ▸ | ITGAV | P06756 | 8/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382782 | 0.95 | ITGB3 (0.54) | ITGB3ITGAVITGA2BCASP3HDAC8 | |
| SCHEMBL382777 | 0.92 | ITGB3 (0.55) | ITGB3ITGAVITGA2BCASP3MEN1 | |
| SCHEMBL6507021 | 0.88 | ITGB3 (0.41) | ITGB3ITGAVITGA2BCASP3 | |
| SCHEMBL381839 | 0.87 | ITGB3 (0.54) | ITGB3ITGAVITGA2BHDAC8HDAC6 | |
| SCHEMBL382037 | 0.87 | ITGB3 (0.55) | ITGB3ITGAVITGA2BALDH1A1MEN1 | |
| SCHEMBL383239 | 0.87 | ITGB3 (0.55) | ITGB3ITGAVITGA2BHDAC8HDAC6 | |
| SCHEMBL382291 | 0.86 | ITGB3 (0.43) | ITGB3ITGAVITGA2BCASP3EPHX2 | |
| SCHEMBL382444 | 0.85 | ITGB3 (0.75) | ITGB3ITGAVITGA2BALDH1A1LMNA | |
| SCHEMBL6505536 | 0.85 | ITGB3 (0.48) | ITGB3ITGAVITGA2BHDAC8HDAC6 | |
| SCHEMBL382514 | 0.85 | ITGB3 (0.52) | ITGB3ITGAVITGA2BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | claimed |
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |