Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345950 | 0.82 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL7351385 | 0.80 | ALDH1A1 (0.54) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL21834896 | 0.76 | MEN1 (0.52) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL28252759 | 0.75 | MEN1 (0.41) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL5540573 | 0.74 | ALDH1A1 (0.34) | ALDH1A1MAPTKDM4ENSD2ADRA2C | |
| SCHEMBL7345538 | 0.73 | CYP2D6 (0.43) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL6196442 | 0.71 | MEN1 (0.45) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL3697070 | 0.71 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL9330383 | 0.71 | MEN1 (0.47) | MEN1KMT2AALDH1A1MAPTADRA2A | |
| SCHEMBL7352919 | 0.70 | POLB (0.37) | MEN1KMT2AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414825-B9 | THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE | ASTRAZENECA AB (SE) | 2009-09-16 | — | — | EP | disclosed |
| EP-1414825-B1 | THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE | ASTRAZENECA AB (SE) | 2007-09-26 | — | — | EP | disclosed |