Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.67 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043277 | 1.00 | HTR2C (0.67) | HTR2CMTNR1AMTNR1BHDAC6HDAC8 | |
| SCHEMBL11033586 | 0.88 | HTR2C (0.68) | HTR2CMTNR1AMTNR1BHDAC6HDAC8 | |
| SCHEMBL3951049 | 0.86 | HTR2C (0.63) | HTR2CHDAC6HDAC8HDAC11PRMT5 | |
| SCHEMBL3951044 | 0.86 | HTR2C (0.63) | HTR2CHDAC6HDAC8HDAC11PRMT5 | |
| SCHEMBL29162348 | 0.77 | HTR2C (0.73) | HTR2CMTNR1AMTNR1BHDAC6HDAC8 | |
| SCHEMBL30839291 | 0.77 | HTR2C (0.73) | HTR2CMTNR1AMTNR1BHDAC6HDAC8 | |
| SCHEMBL25521336 | 0.77 | HTR2C (0.73) | HTR2CMTNR1AMTNR1BHDAC6HDAC8 | |
| SCHEMBL22930056 | 0.77 | HTR2C (0.77) | HTR2CMTNR1AMTNR1BHDAC6HDAC8 | |
| SCHEMBL767962 | 0.77 | HTR2C (0.68) | HTR2CMTNR1AMTNR1BHDAC6HDAC8 | |
| SCHEMBL767963 | 0.77 | HTR2C (0.68) | HTR2CMTNR1AMTNR1BHDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268640-B1 | PROCESS FOR PREPARING ENANTIOMERICALLY PURE INDOLOPYRIDINES | 4SC AG (DE) | 2016-10-12 | — | — | EP | disclosed |
| EP-2098524-A1 | Process for preparing enantiomerically pure indolopyrinidines | 4SC AG (DE) | 2009-09-09 | — | — | EP | disclosed |
| EP-2033962-A1 | Tetracyclic indolopyridines as EG5 inhibitors | 4SC AG (DE) | 2009-03-11 | — | — | EP | disclosed |