Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 14/20 | 0.68 |
| ▸ | ITGAV | P06756 | 14/20 | 0.68 |
| ▸ | ITGA2B | P08514 | 14/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | MTTP | P55157 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382754 | 0.96 | ITGB3 (0.75) | ITGB3ITGAVITGA2BPKMALDH1A1 | |
| SCHEMBL382269 | 0.91 | ITGB3 (0.75) | ITGB3ITGAVITGA2BALDH1A1ITGB1 | |
| SCHEMBL382633 | 0.90 | ITGB3 (0.68) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL419977 | 0.90 | ITGB3 (0.76) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL6499246 | 0.90 | ITGB3 (0.67) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL382937 | 0.88 | ITGB3 (0.66) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL382271 | 0.88 | ITGB3 (0.65) | ITGB3ITGAVITGA2BLMNAITGB1 | |
| SCHEMBL381993 | 0.88 | ITGB3 (0.65) | ITGB3ITGAVITGA2BALDH1A1LMNA | |
| SCHEMBL381996 | 0.88 | ITGB3 (0.75) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL382329 | 0.88 | ITGB3 (0.75) | ITGB3ITGAVITGA2BITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | claimed |
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |