Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.49 |
| ▸ | RAF1 | P04049 | 13/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 4/20 | 0.45 |
| ▸ | DAPK1 | P53355 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3827876 | 0.91 | RAF1 (0.48) | BRAFRAF1TNK2MAP4K2CSF1R | |
| SCHEMBL3825775 | 0.86 | TNK2 (0.56) | BRAFRAF1TNK2MAP4K2CSF1R | |
| SCHEMBL3825382 | 0.86 | LCK (0.51) | BRAFRAF1MAPK14 | |
| SCHEMBL3825076 | 0.80 | LCK (0.49) | BRAFRAF1CSF1RDAPK1MAPK14 | |
| SCHEMBL3827892 | 0.79 | TNK2 (0.56) | BRAFRAF1TNK2MAP4K2CSF1R | |
| SCHEMBL3137374 | 0.79 | TNK2 (0.66) | BRAFRAF1TNK2MAP4K2CSF1R | |
| SCHEMBL3829466 | 0.79 | CSF1R (0.61) | BRAFRAF1TNK2MAP4K2CSF1R | |
| SCHEMBL3827191 | 0.78 | BTK (0.52) | BRAFRAF1CSF1RDAPK1 | |
| SCHEMBL3129999 | 0.77 | TNK2 (0.56) | BRAFRAF1TNK2MAP4K2CSF1R | |
| SCHEMBL3832182 | 0.77 | MAPT (0.50) | BRAFRAF1TNK2MAP4K2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | claimed |
| JP-2007500725-A | — | — | 2007-01-18 | — | — | JP | claimed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | claimed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | claimed |
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | disclosed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | disclosed |