Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 6/20 | 0.61 |
| ▸ | DAPK1 | P53355 | 3/20 | 0.61 |
| ▸ | RAF1 | P04049 | 11/20 | 0.51 |
| ▸ | BRAF | P15056 | 11/20 | 0.51 |
| ▸ | LCK | P06239 | 4/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | TEK | Q02763 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830709 | 0.93 | CSF1R (0.58) | CSF1RDAPK1RAF1BRAFLCK | |
| SCHEMBL3825451 | 0.88 | BTK (0.51) | CSF1RDAPK1LCKKDRMAPK14 | |
| SCHEMBL3825108 | 0.88 | CSF1R (0.52) | CSF1RDAPK1RAF1BRAFLCK | |
| SCHEMBL3827876 | 0.87 | RAF1 (0.48) | CSF1RDAPK1RAF1BRAFMAPK14 | |
| SCHEMBL3830666 | 0.87 | LCK (0.57) | CSF1RDAPK1RAF1BRAFLCK | |
| SCHEMBL3825040 | 0.87 | BTK (0.49) | CSF1RDAPK1BRAFLCKABL1 | |
| SCHEMBL3825126 | 0.86 | BTK (0.49) | CSF1RDAPK1RAF1BRAFLCK | |
| SCHEMBL3830993 | 0.85 | BTK (0.49) | CSF1RDAPK1LCKJAK3 | |
| SCHEMBL3830881 | 0.85 | BTK (0.49) | CSF1RDAPK1RAF1BRAFLCK | |
| SCHEMBL3825146 | 0.85 | BTK (0.44) | CSF1RDAPK1RAF1BRAFLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | disclosed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | disclosed |