Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 12/20 | 0.43 |
| ▸ | RAF1 | P04049 | 11/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3832068 | 0.93 | LCK (0.49) | LCKMAPK14KDRCSF1RDAPK1 | |
| SCHEMBL3825076 | 0.92 | LCK (0.49) | LCKMAPK14KDRCSF1RDAPK1 | |
| SCHEMBL3825108 | 0.90 | CSF1R (0.52) | LCKMAPK14KDRCSF1RDAPK1 | |
| SCHEMBL3830709 | 0.89 | CSF1R (0.58) | LCKMAPK14KDRCSF1RDAPK1 | |
| SCHEMBL3828846 | 0.88 | BTK (0.44) | LCKCSF1RDAPK1BRAFRAF1 | |
| SCHEMBL3830666 | 0.87 | LCK (0.57) | LCKMAPK14KDRCSF1RDAPK1 | |
| SCHEMBL3825410 | 0.87 | CSF1R (0.47) | LCKMAPK14KDRCSF1RDAPK1 | |
| SCHEMBL3829466 | 0.81 | CSF1R (0.61) | LCKMAPK14KDRCSF1RDAPK1 | |
| SCHEMBL3134068 | 0.81 | LCK (0.48) | LCKMAPK14KDRCSF1RDAPK1 | |
| SCHEMBL3825126 | 0.81 | BTK (0.49) | LCKCSF1RDAPK1BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | disclosed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | disclosed |