Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A1 | P53985 | 20/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.74 |
| ▸ | SLC16A7 | O60669 | 1/20 | 0.65 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.53 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826712 | 0.99 | SLC16A1 (0.73) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL3826720 | 0.99 | SLC16A1 (0.73) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL3826715 | 0.91 | SLC16A1 (0.72) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL4845192 | 0.89 | SLC16A1 (0.69) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL5864670 | 0.87 | SLC16A1 (0.67) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL3828116 | 0.85 | SLC16A1 (0.62) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL3833017 | 0.85 | SLC16A1 (0.75) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL4847425 | 0.85 | SLC16A1 (0.75) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL3829937 | 0.85 | SLC16A1 (0.75) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 | |
| SCHEMBL5094503 | 0.85 | SLC16A1 (0.61) | SLC16A1CYP2C9CYP3A4SLC16A7MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414825-B9 | THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE | ASTRAZENECA AB (SE) | 2009-09-16 | — | — | EP | disclosed |
| EP-1414825-B1 | THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE | ASTRAZENECA AB (SE) | 2007-09-26 | — | — | EP | disclosed |