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Sugi Predict / Targets / SLC16A1

SLC16A1

Monocarboxylate transporter 1 · P53985 · SLC16A1 on Sugi Atlas →

16,896 patent compounds predicted against SLC16A1, 9,530 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL929883 SCHEMBL929883 0.60 17/20
SCHEMBL927777 SCHEMBL927777 0.39 16/20
SCHEMBL927411 SCHEMBL927411 0.50 15/20
SCHEMBL927983 SCHEMBL927983 0.53 13/20
SCHEMBL928309 SCHEMBL928309 0.52 13/20
SCHEMBL926958 SCHEMBL926958 0.61 12/20
SCHEMBL928596 SCHEMBL928596 0.52 12/20
SCHEMBL928717 SCHEMBL928717 0.59 11/20
SCHEMBL2010303 SCHEMBL2010303 0.35 10/20
Bindarit Bindarit (SCHEMBL187885) 0.55 9/20
Bindarit Bindarit (SCHEMBL371677) 0.54 9/20
SCHEMBL928508 SCHEMBL928508 0.48 9/20
SCHEMBL2012520 SCHEMBL2012520 0.36 8/20
SCHEMBL163226 SCHEMBL163226 0.47 7/20
SCHEMBL927364 SCHEMBL927364 0.47 7/20
SCHEMBL927862 SCHEMBL927862 0.46 7/20
Clobuzarit Clobuzarit (SCHEMBL187456) 0.62 6/20
SCHEMBL2086920 SCHEMBL2086920 0.61 6/20
SCHEMBL2086921 SCHEMBL2086921 0.61 6/20
SCHEMBL2087443 SCHEMBL2087443 0.60 6/20

Clinical trials — most relevant to SLC16A1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Organic Cation Transporter 1 (OCT1), on Response to Metformin in Healthy Subjects PHASE4COMPLETED
Genetic Basis for Variation in the Renal Elimination of Metformin PHASE4COMPLETED
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors PHASE2ACTIVE_NOT_RECRUITING
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia PHASE1/PHASE2RECRUITING
Effect of Omeprazole on Metformin PHASE1COMPLETED
Safety and Pharmacokinetic Profiles of Two Formulations of CO-1.01 in Patients With Advanced Solid Tumors PHASE1COMPLETED
Open Label Pharmacokinetic-Pharmacogenetic Study on Polymorphisms in the Organic Cation Transporter OCT1 PHASE1COMPLETED
Evaluate the Effect of Vimseltinib on Organic Cation Transporter 2 (OCT2) PHASE1COMPLETED
Vatalanib and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors PHASE1COMPLETED
Inter- and Intra-individual Variations in Metformin Pharmacokinetics - The Importance of Genes and Drug Interactions PHASE1COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters EARLY_PHASE1COMPLETED
Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I EARLY_PHASE1COMPLETED
Sodium Lactate Infusion in GLUT1DS Patients EARLY_PHASE1COMPLETED
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer EARLY_PHASE1UNKNOWN
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors nanUNKNOWN
Erythrocyte Transport of Lactate During Exercise (TELE Project) nanRECRUITING
Register for Patients With Thyroid Hormone Resistance. nanRECRUITING
Oxalate and Citrate in Humans - Response to Citrate nanRECRUITING
Impact of Genetics on Metformin Pharmacokinetics nanCOMPLETED
Harmonic Ratio in Patients With GLUT1 Deficiency Syndrome nanACTIVE_NOT_RECRUITING
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs nanCOMPLETED
Does a Ketogenic Dietary Supplement Reduce Alcohol Withdrawal Symptoms in Humans? nanUNKNOWN
Variations in the DIO2 and MCT10 Genes and Effect of Triiodothyronine Treatment nanCOMPLETED
Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test nanCOMPLETED
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise nanCOMPLETED
Lactate Profile and Fat Oxidation During Exercise nanCOMPLETED
Characterization of Breg Cells nanCOMPLETED
Role of FAPI PET/MR Combined With Gadoxetate Disodium in Assessing Hepatic Malignancies nanUNKNOWN
A Proof-of-concept Study Evaluating the Microbiota-gut-brain Axis nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a SLC16A1 binder may also engage these)

ProteinNameSimilarity
P53986 — 1.000 P53986 →
Q3MHW6 — 1.000 Q3MHW6 →
Q03064 — 1.000 Q03064 →
P53987 — 0.996 P53987 →
P53988 — 0.990 P53988 →
SLC16A7 Monocarboxylate transporter 2 0.984 landscape →
O35440 — 0.984 O35440 →
O70451 — 0.983 O70451 →
Q90632 — 0.976 Q90632 →
Q63344 — 0.976 Q63344 →
P57788 — 0.973 P57788 →
Q8TF71 — 0.971 Q8TF71 →
G5E8K6 — 0.963 G5E8K6 →
Q91Y77 — 0.958 Q91Y77 →
A1L1W9 — 0.957 A1L1W9 →
Q3U9N9 — 0.956 Q3U9N9 →
P57787 — 0.946 P57787 →
B0JZE1 — 0.945 B0JZE1 →
A2SWM2 — 0.944 A2SWM2 →
Q6NT16 — 0.944 Q6NT16 →
Q5M7K3 — 0.943 Q5M7K3 →
O35910 — 0.943 O35910 →
B0WC46 — 0.942 B0WC46 →
Q6DEJ6 — 0.942 Q6DEJ6 →
Q8NHS3 — 0.941 Q8NHS3 →
Q2XWK0 — 0.941 Q2XWK0 →
Q9WU81 — 0.941 Q9WU81 →
Q8R090 — 0.940 Q8R090 →
Q7SY29 — 0.940 Q7SY29 →
Q6PDF3 — 0.939 Q6PDF3 →