Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.72 |
| ▸ | IGF1R | P08069 | 13/20 | 0.72 |
| ▸ | ERBB4 | Q15303 | 12/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.72 |
| ▸ | ERBB3 | P21860 | 11/20 | 0.72 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.62 |
| ▸ | AURKA | O14965 | 4/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.57 |
| ▸ | ABL1 | P00519 | 3/20 | 0.57 |
| ▸ | LCK | P06239 | 3/20 | 0.57 |
| ▸ | FYN | P06241 | 3/20 | 0.57 |
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | LYN | P07948 | 3/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | FLT1 | P17948 | 3/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.57 |
| ▸ | FLT4 | P35916 | 3/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6109795 | 0.88 | EGFR (0.73) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL6109791 | 0.88 | EGFR (0.73) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4819751 | 0.84 | EGFR (1.00) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL6430800 | 0.84 | EGFR (1.00) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL6108400 | 0.81 | EGFR (0.78) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL3819964 | 0.81 | EGFR (0.78) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4822802 | 0.79 | EGFR (0.73) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4822825 | 0.79 | EGFR (0.73) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4822096 | 0.77 | EGFR (0.75) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL6220226 | 0.77 | EGFR (0.75) | EGFRIGF1RERBB4ERBB2ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730148-A4 | AMINOBENZOXAZOLES AS THERAPEUTIC AGENTS | ABBOTT LAB (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1730148-A2 | AMINOBENZOXAZOLES AS THERAPEUTIC AGENTS | Abbott Laboratories (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005074603-A2 | AMINOBENZOXAZOLES AS THERAPEUTIC AGENTS | ABBOTT LABORATORIES (US) | 2005-08-18 | — | — | WO | disclosed |