Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 4/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831176 | 0.94 | NTRK1 (0.52) | NTRK1NPC1POLBTDO2ALDH1A1 | |
| SCHEMBL3831198 | 0.89 | NPC1 (0.47) | NTRK1NPC1POLB | |
| SCHEMBL3833669 | 0.88 | NPC1 (0.58) | NTRK1NPC1POLBTDO2ALDH1A1 | |
| SCHEMBL3832804 | 0.88 | NTRK1 (0.44) | NTRK1NPC1POLBALDH1A1S1PR1 | |
| SCHEMBL27618544 | 0.85 | NPC1 (0.42) | NTRK1NPC1POLBALDH1A1S1PR1 | |
| SCHEMBL3827436 | 0.85 | DGAT2 (0.47) | NTRK1NPC1POLBALDH1A1S1PR1 | |
| SCHEMBL3829509 | 0.85 | NPC1 (0.42) | NTRK1NPC1POLBDGAT2 | |
| SCHEMBL27637724 | 0.84 | NPC1 (0.51) | NTRK1NPC1POLBALDH1A1DGAT2 | |
| SCHEMBL1203559 | 0.82 | NPC1 (0.55) | NTRK1NPC1POLBALDH1A1KDR | |
| SCHEMBL1201954 | 0.81 | NPC1 (0.48) | NTRK1NPC1POLBALDH1A1DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460071-B1 | N-HETEROARYLNICOTINAMIDE DERIVATIVES | MITSUI CHEMICALS AGRO INC (JP) | 2009-09-16 | — | — | EP | disclosed |
| CN-100425609-C | N-Heteroaryl Nicotinamide Derivatives | SANKYO AGRO CO LTD (JP) | 2008-10-15 | — | — | CN | disclosed |
| US-7015236-B2 | N-heteroarylnicotinamide derivatives | SANKYO AGRO COMPANY, LIMITED (JP) | 2006-03-21 | — | — | US | disclosed |
| CN-1692111-A | N-Heteroaryl Nicotinamide Derivatives | SANKYO AGRO CO LTD (JP) | 2005-11-02 | — | — | CN | disclosed |
| US-20050004368-A1 | N-heteroarylnicotinamide derivatives | SANKYO ARGO COMPANY LIMITED (JP) | 2005-01-06 | — | — | US | disclosed |
| EP-1460071-A1 | N-HETEROARYLNICOTINAMIDE DERIVATIVES | Sankyo Agro Company, Limited (JP) | 2004-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004368-A1 | N-heteroarylnicotinamide derivatives | CBR3, CBR1, NAT1 | NTRK1 881/4885NPC1 673/4885POLB 3500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.