Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27637724 | 0.87 | NPC1 (0.51) | NPC1POLBNTRK1SCDSCD5 | |
| SCHEMBL3829469 | 0.87 | NPC1 (0.45) | NPC1POLBNTRK1SCDSCD5 | |
| SCHEMBL3832541 | 0.87 | NPC1 (0.42) | NPC1POLBNTRK1SCDSCD5 | |
| SCHEMBL1203021 | 0.86 | NPC1 (0.48) | NPC1POLBNTRK1SCDSCD5 | |
| SCHEMBL1203559 | 0.85 | NPC1 (0.55) | NPC1POLBNTRK1SCDSCD5 | |
| SCHEMBL1202926 | 0.84 | NPC1 (0.46) | NPC1POLBNTRK1SCDSCD5 | |
| SCHEMBL27637717 | 0.84 | NPC1 (0.48) | NPC1POLBNTRK1SCDSCD5 | |
| SCHEMBL1201954 | 0.84 | NPC1 (0.48) | NPC1POLBNTRK1SCDSCD5 | |
| SCHEMBL3829984 | 0.83 | NPC1 (0.46) | NPC1POLBNTRK1SCDSCD5 | |
| SCHEMBL1201890 | 0.83 | MAPT (0.50) | NPC1POLBNTRK1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460071-B1 | N-HETEROARYLNICOTINAMIDE DERIVATIVES | MITSUI CHEMICALS AGRO INC (JP) | 2009-09-16 | — | — | EP | disclosed |
| US-7015236-B2 | N-heteroarylnicotinamide derivatives | SANKYO AGRO COMPANY, LIMITED (JP) | 2006-03-21 | — | — | US | disclosed |
| US-20050004368-A1 | N-heteroarylnicotinamide derivatives | SANKYO ARGO COMPANY LIMITED (JP) | 2005-01-06 | — | — | US | disclosed |
| EP-1460071-A1 | N-HETEROARYLNICOTINAMIDE DERIVATIVES | Sankyo Agro Company, Limited (JP) | 2004-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004368-A1 | N-heteroarylnicotinamide derivatives | CBR3, CBR1, NAT1 | NPC1 673/4885POLB 3500/4885NTRK1 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.