Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 7/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830796 | 0.95 | MET (0.52) | METFLT3AXLIRAK4EGFR | |
| SCHEMBL4418360 | 0.91 | MET (0.49) | METFLT3AXLIRAK4 | |
| SCHEMBL3848541 | 0.90 | MET (0.55) | METFLT3IRAK4EGFR | |
| SCHEMBL19689584 | 0.89 | MET (0.52) | METFLT3AXLIRAK4EGFR | |
| SCHEMBL3854982 | 0.89 | MET (0.49) | METFLT3IRAK4EGFR | |
| SCHEMBL15103894 | 0.89 | MET (0.54) | METFLT3IRAK4 | |
| SCHEMBL2231889 | 0.89 | MET (0.49) | METFLT3AXLIRAK4 | |
| SCHEMBL15520694 | 0.89 | MET (0.49) | METFLT3AXLIRAK4 | |
| SCHEMBL2331712 | 0.89 | MET (0.53) | METFLT3IRAK4EGFR | |
| SCHEMBL3836125 | 0.88 | MET (0.50) | METFLT3AXLIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |
| EP-2612853-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2013-07-10 | — | — | EP | disclosed |